Graves Disease - Symptoms, Causes & Treatment

Written By: Dr. Yasmeen Ajaz

Updated On:January 30, 2025

Read more.

blog

What is Graves’ Disease

Under your skin, near the front of your neck, is a little, butterfly-shaped endocrine gland called the thyroid. The primary function of the thyroid is to control the rate at which your body converts food into energy by producing certain hormones. This process is known as metabolic rate. In Graves' disease, an autoimmune condition, your immune system targets healthy thyroid gland tissue for unclear reasons. Hyperthyroidism is a disorder where your thyroid gland produces excessive amounts of thyroid hormone, and this is the most prevalent cause of Graves’ disease.

Causes of Graves’ Disease

The aetiology of autoimmune disorders such as Graves’ disease remains unknown. Your immune system produces an excess of an antibody known as thyroid-stimulating immunoglobulin (TSI) due to an external cause. Your thyroid produces too many thyroid hormones when TSI binds to healthy thyroid cells. The following environmental conditions, in addition to genetic susceptibility, may have combined to precipitate the attack: Stress, illness or virus, and pregnancy.

Symptoms of Graves’ Disease

Graves' disease symptoms often appear gradually, sometimes taking weeks or months to manifest Hyperthyroidism, a condition brought on by Graves' disease, accelerates several bodily processes. The signs of hyperthyroidism are numerous. Some of these symptoms may affect you more than others, or you may have many of them at once. Hyperthyroidism symptoms might include:

  • Fast heart palpitations
  • Feeling uneasy or anxious
  • Weight loss
  • Increased appetite
  • Increased frequency of bowel motions and/or diarrhoea
  • Thin, warm, or wet skin
  • Heat intolerance and profuse perspiration
  • Insomnia, or trouble falling asleep
  • Goiter, or enlarged thyroid gland
  • Hair loss as well as changes in hair texture
  • Menstrual changes
  • Weakening of the muscles

Graves’ disease can also impact your vision with symptoms, such as irritation, swelling, bulging, and pain in the eye in addition to blurred vision.

When to see a doctor for Graves’ Disease

The symptoms of Graves' disease can be brought on by a variety of illnesses. If you suspect any possible Graves' disease-related issues, consult your physician right away for a precise and timely diagnosis.

If you start to have symptoms connected to your heart, such as an irregular or fast heartbeat, or if you start to lose your vision, get immediate attention.

Graves’ Disease Risk Factors

Graves’ disease may impact anyone; however, below is a set of risk factors that heighten your chances of having Graves’ disease: 

  • Family history
  • Age
  • Emotional or physical stress
  • Pregnancy
  • Smoking
  • Being a female

Graves’ Disease Complications 

Graves' illness complications might include:

  • Pregnancy-related problems. Preeclampsia, miscarriage, premature delivery, fetal thyroid malfunction, inadequate fetal development, and maternal heart failure are among the potential pregnancy concerns associated with Graves' illness. Maternal preeclampsia is characterized by elevated blood pressure together with other critical indications.
  • Thyroid storm. Thyrotoxic crisis, commonly referred to as thyroid storm, is an uncommon but potentially fatal side effect of Graves' illness. It is more common when severe hyperthyroidism is left untreated or receives insufficient care. Many symptoms, including fever, sweats, vomiting, diarrhea, disorientation, extreme weakness, seizures, irregular heartbeat, jaundice (yellow skin and eyes), severe low blood pressure, and coma, can result from an abrupt and dramatic surge in thyroid hormones. Treatment for thyroid storm has to start right away.
  • Heart conditions. Heart failure as well as abnormalities in the structure and function of the heart muscles, may result from not receiving treatment for Graves' disease.
  • Osteoporosis. Your bones' strength is influenced by the quantity of calcium and other elements they contain. Graves’ disease impacts your body's capacity to absorb calcium into your bones.

Graves’ Disease Diagnosis

In addition to performing a physical examination, your doctor will inquire about your symptoms and medical history, including any family history of thyroid illness. To confirm the diagnosis of Graves' disease, they could additionally request the following tests:

  • Thyroid blood tests: These blood tests measure the quantities of thyroid-stimulating hormone (TSH) and thyroid hormone in your blood. An excess of hormone is being produced by your thyroid gland if your TSH level is low. Its overabundance results in your pituitary gland producing less TSH.
  • Thyroid antibody blood tests: These assays aid in the diagnosis of various autoimmune thyroid disorders. Thyroid-stimulating antibodies (TSI) and thyroid-binding inhibitory immunoglobulins (TBII) are the two kinds of antibodies associated with Graves' illness.
  • Thyroid uptake and scan: This test involves ingesting a small dose of radioactive iodine. Your thyroid's absorption of radioactive iodine will be measured by your healthcare professional. Elevated levels of iodine uptake may indicate Graves' illness.
  • Doppler blood flow measurement, often known as Doppler ultrasound: This test employs sound waves to identify elevated thyroid blood flow brought on by Graves' illness. If you are in a situation where radioactive iodine absorption is not a suitable choice for you—for example, during pregnancy or breastfeeding—your provider may prescribe this test.

Graves’ Disease Treatment 

Graves' disease is a chronic (lifelong) illness. Treatments, however, can regulate your thyroid hormone levels. Even a temporary remission of the condition may result in medical therapy. Graves' illness is treated with the following:

  • Beta-blockers: For Graves' illness, beta-blockers like propranolol and metoprolol are frequently the first line of therapy. These drugs control your heart rate and safeguard your heart until further therapies for hyperthyroidism become effective. The synthesis of thyroid hormone is not stopped by these drugs.
  • Antithyroid drugs: Antithyroid drugs, such as propylthiouracil and methimazole (Tapazole®), prevent your thyroid from producing thyroid hormone. These drugs can induce low white blood cell counts and skin rashes in a small number of patients, which may raise your risk of infection.
  • Radioiodine therapy: In radioiodine therapy, a single dosage of tablets or liquids containing radioactive iodine is given. Thyroid gland cells are slowly killed by radiation over two to three months. As your thyroid gland shrinks, your hormone levels go back to normal.
  • Surgery: Your thyroid gland may be removed whole or in part during a thyroidectomy. After surgery, some patients develop hypothyroidism or inadequate synthesis of thyroid hormones. If you have this condition, you may need to take a prescription for thyroid replacement hormones.

Graves’ Disease Prevention

Given that the cause of Graves’ disease has not been consensually established, there are currently no methods of prevention.

References

Bartalena, L. (2013). Diagnosis and management of Graves disease: a global overview. Nature Reviews Endocrinology9(12), 724-734.

Burch, H. B., & Cooper, D. S. (2015). Management of Graves disease: a review. Jama314(23), 2544-2554.

Davies, T. F., Andersen, S., Latif, R., Nagayama, Y., Barbesino, G., Brito, M., ... & Kahaly, G. J. (2020). Graves’ disease. Nature reviews Disease primers6(1), 52.

Menconi, F., Marcocci, C., & Marinò, M. (2014). Diagnosis and classification of Graves' disease. Autoimmunity reviews13(4-5), 398-402.

Smith, T. J., & Hegedüs, L. (2016). Graves’ disease. New England Journal of Medicine375(16), 1552-1565.

Meet our doctors from the Endocrinology department

Mohamad Sohil
MS
Endocrinology
French
Arabic, English, French
BOOK NOW
Yasmeen Ajaz
MBBS, MD, FRCP(EDIN),EBEEDM,SCE,PGDD
Endocrinology
Indian
Arabic, English, Hindi, Urdu
BOOK NOW
Iryna Shatokhina
MBBS, MD, PhD.
Endocrinology
Ukranian
English, Russian, Ukrainian
BOOK NOW
AlShimaa Rezk
MBBCh, MD
Endocrinology
Egyptian
Arabic, English
BOOK NOW
Ghaida Kaddaha
MBBS, MRCP (UK), FRCP (London)
Endocrinology
Lebanese
Arabic, English, French, Urdu
BOOK NOW
Zeenat Naseeb Abdul Wahid
MBBCh, MRCP, MRCP Endocrinology and Diabetes, PG Diploma in Diabetes, International Fellowship in Endocrinology and Diabetes, FRCP
Endocrinology
Pakistani
English, Arabic, Urdu
BOOK NOW
Brian Mtemererwa
MBChB, CCT (UK), MRCP(UK)
Endocrinology
British
English, Shona
BOOK NOW
Shayesteh Khalili
MBBS, MD, Board Cert in Int Med Fellowship Endoc
Endocrinology
Canadian
English, Persian
BOOK NOW
Similar Posts
Scroll Top